African swine fever vaccine successfully developed in the laboratory stage in my country

Yesterday, the Chinese Academy of Agricultural Sciences held a scientific research progress briefing, which showed that the African swine fever vaccine independently developed by the Harbin Veterinary Research Institute has achieved phased results, and the laboratory's scientific research experiments have also performed well. As soon as this achievement came out, relevant media rushed to report it all over the world. It is reported that a media in the United States reported that the effective rate of this vaccine against African swine fever can reach 92%.

How will African swine fever affect the pig industry?

Affected by the epidemic, the inter-provincial transfer of live pigs across the country is almost completely restricted. For the domestic pig industry, African swine fever may become normal for a long period of time in the future, and the restriction of live pigs may continue, and the prevention and control of the epidemic may also With further upgrades, its impact on the domestic pig industry may continue to increase.

In general, the impact of African swine fever on the pig industry can be summarized in the following five points: 1. The circulation of live pigs is restricted, and the price of production and sales is differentiated; 2. The production capacity is accelerated, and the process of the pig cycle is rewritten; 3. The distribution mode of live pigs is adjusted. , Meat adjustment gradually replaces pig adjustment; 4. The exit of retail investors is accelerated, and the process of large-scale is accelerated;

What are the phased results of the African swine fever vaccine candidate?

According to Bu Zhigao, director of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, the main phased achievements in the creation of the African swine fever vaccine mainly include the following five items: First, the African swine fever strain was successfully tested in the laboratory. The second is to prove that the selected vaccine strain has a good immune protection effect in the experimental research process; the third is to confirm the genetic stability of the two candidate vaccines in vivo, and the continuous bed test in pigs shows that no virulence appears Strong return phenomenon, good stability; Fourth, to prove the safety of large-dose and repeated-dose vaccination; Fifth, the pre-clinical pilot product process research has been preliminarily completed.

What are the future research directions for African swine fever vaccine candidates?

It is reported that the animal infection cell model has been established in the laboratory, and the pre-clinical pilot product process research has also been initially completed. In terms of future research work, the Chinese Academy of Agricultural Sciences will accelerate the pilot and clinical trials, as well as various research work on vaccine production, based on the research progress in the vaccine laboratory stage. Not only that, the Chinese Academy of Agricultural Sciences also plans to carry out some research work such as diagnostic testing, disinfection and pest control to ensure that the vaccine can be fully put into production. It can be said that the future research direction of the Chinese Academy of Agricultural Sciences has given the country and the industry a shot in the arm.

Future scientific research directions for African swine fever candidate vaccines

The successful development of this candidate vaccine not only marks great progress in the control of African swine fever, but also demonstrates my country's strong scientific and technological capabilities. But at present, the research and development of vaccines is still in its infancy, and more in-depth research is still needed if it is to be fully and widely put into use.

African swine fever vaccine candidate has made * progress, what is the significance of this progress?

Since the first case was confirmed in Shenyang, Liaoning on August 3 last year, African swine fever has spread across the country, and both pig farmers and the general public have been affected to varying degrees. However, the current African swine fever candidate vaccine has made the most progress. The Harbin Veterinary Research Institute issued an announcement the day before yesterday, that is, on May 23: The National African swine fever laboratory of Harbin Veterinary Research has successfully isolated the African swine fever strain and infected it. The biological characteristics such as sex, pathogenicity and infectivity have been systematically studied, and animal infection models have been successfully established.

African swine fever vaccine candidate has made * progress, what is the significance of this progress?

We all know that African swine fever virus has many types of viruses, a large number, complex and diverse immune escape mechanisms, and can also evade the clearance of host immune cells. However, the current research and development of African swine fever vaccine has made significant progress, which may be successfully developed before Europe and the United States.

1. At present, the first strain of African swine fever virus has been isolated in my country, a virus cell isolation and culture system and animal infection model have been established, and its biological characteristics such as infectivity, pathogenicity and transmission ability have been systematically studied , and revealed the genomic characteristics and evolutionary relationship of African swine fever epidemic strains in my country.

2. Created candidate vaccines for African swine fever. Laboratory studies have proved that two candidate vaccine strains have good biological safety and immune protection effects.

3. The two candidate vaccine strains have strong genetic stability in vitro and in vivo. The two candidate vaccine strains were continuously passaged in primary cells in vitro, and their biological characteristics and genome sequences did not change significantly, and the pigs were continuously passaged, and no obvious phenomenon of virulence reversion was found.

4. The minimum protective vaccination dose has been clarified, proving the safety of high-dose and repeated-dose vaccination.

5. The pre-clinical pilot product process research has been preliminarily completed. At present, the production seed bank of two candidate vaccines has been established, the purity and exogenous virus inspection of vaccine production seed batches have been preliminarily completed, and the cell culture and freeze-drying process of candidate vaccines have been preliminarily optimized.

African swine fever vaccine candidate has made * progress, what is the significance of this progress?

This test successfully isolated the African swine fever domestically popular strain, conducted a systematic study on the virus's biological characteristics such as infectivity, pathogenicity, transmissibility, and transmission route, and preliminarily clarified the genome characteristics and characteristics of the strain. The evolutionary relationship has laid an important foundation for virus detection technology and vaccine research and development, and provided an important scientific basis for the prevention and control of ASF epidemics in my country.

The above is the progress and significance of the candidate vaccine for African swine fever. At present, the country attaches great importance to this aspect. Although the vaccine has not been successfully developed since the discovery of the African swine fever virus, Chinese scientists have created a candidate vaccine for African swine fever, and two The candidate vaccine strain also has good biological safety and immune protection effect. It is believed that the African swine fever vaccine will be successfully developed.